Please read the below information to learn more about the assessments and tests involved in this sub-study.

• Urine tests: Your urine will be collected daily for the first 5 days of this sub study. We will check if any ‘biomarkers’ are being released from the kidneys and if these markers could be used early to detect kidney damage.

We will also be using results from your blood tests that are already being done by the hospital. We will not take any additional blood tests from you.

Risks:

• The risks of participating in this sub-study are low - the only extra samples needed are urine samples, which carry no extra risk.

Benefits:

• You may not benefit from this study, but it is possible that the results from this study will help us better understand what happens to the kidneys during infection.
• Research like this may also help us to improve the care and diagnosis of patients with kidney damage into the future.

• Your information will be kept strictly confidential.
• Your information collected for this sub-study will be stored in a database hosted by the Menzies School of Health Research. This data will be de-identified, meaning you would not be able to be identified by these data.

• Your samples will be assigned a unique identifying code, but not your name or other individually identifiable information.
• If you consent to future research, any leftover urine samples will be stored at the Menzies School of Health Research in Darwin, indefinitely, so they can be used for future research relating to extension of this project or closely related projects.
• If you do not consent to future research, your samples will be destroyed at the completion of the sub study.
• Future research is important to advance science and public health. Your samples may be used with information from other sources outside typical clinical research settings (e.g., from public research databases), however, they will not be combined with other information in a way that could identify you.
• You may request that your stored samples be destroyed at any time by contacting the sub study lead, using the contact details provided.

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You can withdraw from the sub study and/or from future use of your samples at any time, just notify a member of the SNAP study team.

If you withdraw, we will keep any information we have collected about you up until you withdraw. If you do not agree with this, you should not join this substudy.