Intro Paragraph

To submit a new proposal for the SNAP Trial, please use this Expression of Interest form here.

Approved Nested Trials / Sub-Studies

Proposed nested trials/sub-studies that have been approved by the Global Trial Steering Committee (GSTC).

Cell-free DNA

Cell-free DNA is a Versatile Analyte to Monitor Complications and Guide Treatment Duration in Staphylococcus aureus Bacteremia

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Canada
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Active Substudy
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Recruiting

C-SNAP

C-SNAP: Evaluating the prevalence of vitamin C deficiency and plasma vitamin C level decay in a prospective sample of patients with Staphylococcus aureus bacteraemia enrolled in the SNAP trial

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New Zealand
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Active Substudy
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Recruiting

PWID

People Who Inject Drugs (PWID) Substudy

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All
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Active Substudy
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Recruiting

SNOOPY

Staphylococcus aureus Network: ultrasound for diagnosis of endovascular disease in Paediatrics and Youth

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Australia
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Active Substudy
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Recruiting

CAESAR – Study 1

Relation between cefazolin and flucloxacillin exposure and outcome

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The Netherlands
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Active Substudy
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Recruiting

CAESAR – Study 2

Difference in the emergence of resistant pathogens between cefazolin and flucloxacillin

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The Netherlands
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Active Substudy
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Recruiting

SIMPLY SNAP

Evaluating the impact of a SIMPlified Layered consent process versus a conventional informed consent form on recruitment of potential participants to a large platform clinical trial: a pragmatic nested randomized controlled trial

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Canada
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Active Substudy
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Recruiting

O-SNAP

Optimizing antibiotic dosing in the Staphylococcus aureus Network Adaptive Platform trial

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Australia
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Active Substudy
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Recruiting

CERT-SNAP

Combination Cefazolin with Ertapenem for methicillin-susceptible Staphylococcus aureus bacteremia.

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Canada
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Active Substudy
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Recruiting

DAPTO-SNAP

Daptomycin vs. Vancomycin for the Treatment of MRSA bacteremia

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Canada, Australia, All Interested
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Active Substudy
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Recruiting

PR-O-SNAP

PK/PD of oral beta-lactam with and without probenecid for treatment of Staphylococcus aureus bacteraemia.

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New Zealand
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Active Substudy
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Completed

SNAPPER

SNAP Prospective Evaluation of Renal effects

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Australia
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Active Substudy
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Completed

Intro Paragraph

Approved Secondary Analyses

Proposed secondary analyses of SNAP data that have been approved by the Global Trial Steering Committee (GSTC).

SNAPstrat

SNAPstrat: Patient stratification using SAB sub-phenotypes

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Any Interested
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In set up

Cef vs Pen

Cefazolin Versus Penicillin for Penicillin-Susceptible Staphylococcus aureus Bacteremia: A Secondary Analysis of the SNAP Backbone Trials

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Australia, New Zealand, Singapore, Canada, Europe, Israel, South Africa
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Bacteriuria

Significance of S. aureus bacteriuria in patients hospitalized with S. aureus bacteremia

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Any Interested
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Stats-GWAS

A statistical genomics framework to improve prediction of treatment outcomes of Staphylococcus aureus bacteraemia (SAB)

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Australia
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Completed

SNAP Team

Co-ordinating Investigators

Meet the SNAP Team
Joshua Davis

Professor Joshua S Davis PhD, FRACP, MBBS (Hons), DTM&H, Grad Cert Pop Health. Infectious Diseases Physician and NHMRC Career Development Fellow at the University of Newcastle and the Menzies School of Health Research.

Steven Tong

Professor Steven YC Tong PhD, FRACP, MBBS (Hons), Grad Dip Epidemiol Biostats, Infectious Diseases Physician with the Victorian Infectious Diseases Service.

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