Published
March 12, 2024

Bacteriuria

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Bacteriuria

This is a substudy within the SNAP trial to test the prognostic significance of Staphylococcus aureus bacteriuria.

  • Bacteriuria refers to the presence of bacteria in urine.
  • Among patients with S. aureus bacteremia (SAB), up to 39% will have concominant positive urine culture for S. aureus
  • Current related studies have conflicting data, suggesting that bacteriuria may be a marker of endocarditis, bone and joint infections, and a predictor of complications and poor outcome of SAB.
What will the substudy involve - more information
  • All patients included in both the SNAP RCT and registry that have available mortality data will be included in this retrospective analysis.
  • The co-primary outcomes include 90-day all-cause mortality and any deep-seated infection (defined as endocarditis or bone and joint) indentified at any time of SAB.
  • Independent variables will include demographics, infection characteristics, including randomization arm, as well as urine culture status - positive or negative.
  • We will also perform a comparison between patients who had or did not have urine culture collection in order to evaluate the applicability of our results for any SAB treatment.

Where will substudy data be collected and stores?

No additional substudy-specific data will be collected.

Microbiological data, as documented in the SNAP CRF will be retrospectively analyzed.

Where will substudy isolates be collected and stores?

No additional isolates will be collected as part of this substudy.

Substudies in Progress

SNAP Trial

CERT-SNAP

Combination Cefazolin with Ertapenem for methicillin-susceptible Staphylococcus aureus bacteremia.

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All Interested
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Substudy in Progress

DAPTO-SNAP

Daptomycin vs. Vancomycin for the Treatment of MRSA bacteremia

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All Interested
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Substudy in Progress

SABSI

Profiling the genetic and epigenetic determinants that predispose to severe manifestations of Staphylococcus aureus bacteremia

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All Interested
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Substudy in Progress

cfDNA

Cell-free DNA is a Versatile Analyte to Monitor Complications and Guide Treatment Duration in Staphylococcus aureus Bacteremia

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Any interested
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Substudy in Progress

SABSI-Outcomes

Derivation and Validation of Phenotypes of Staphylococcus aureus bloodstream infection, with Correlation with Outcome.

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Any Interested
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Substudy in Progress

PR-O-SNAP

PK/PD of oral beta-lactam with and without probenecid for treatment of Staphylococcus aureus bacteraemia.

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New Zealand
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Substudy in Progress
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