SNAP Trial

This will be a secondary analysis of the SNAP trial data to test the prognostic significance of Staphylococcus aureus bacteriuria.

Bacteriuria refers to the presence of bacteria in urine.
Among patients with S. aureus bacteremia (SAB), up to 39% will have concominant positive urine culture for S. aureus
Current related studies have conflicting data, suggesting that bacteriuria may be a marker of endocarditis, bone and joint infections, and a predictor of complications and poor outcome of SAB.

What will the substudy involve - more information

All patients included in both the SNAP RCT and registry that have available mortality data will be included in this retrospective analysis.
The co-primary outcomes include 90-day all-cause mortality and any deep-seated infection (defined as endocarditis or bone and joint) indentified at any time of SAB.
Independent variables will include demographics, infection characteristics, including randomization arm, as well as urine culture status - positive or negative.
We will also perform a comparison between patients who had or did not have urine culture collection in order to evaluate the applicability of our results for any SAB treatment.

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Where will substudy data be collected and stored?

No additional substudy-specific data will be collected.

Microbiological data, as documented in the SNAP CRF will be retrospectively analyzed.

Where will substudy isolates be collected and stored?

No additional isolates will be collected as part of this substudy.

SNAP Proposals

View All Proposals

C-SNAP

C-SNAP: Evaluating the prevalence of vitamin C deficiency and plasma vitamin C level decay in a prospective sample of patients with Staphylococcus aureus bacteraemia enrolled in the SNAP trial

New Zealand

Substudy in Progress

PWID

People Who Inject Drugs (PWID) Substudy

All

Substudy in Progress

Cef vs Pen

Cefazolin Versus Penicillin for Penicillin-Susceptible Staphylococcus aureus Bacteremia: A Secondary Analysis of the SNAP Backbone Trials

Australia, New Zealand, Singapore, Canada, Europe, Israel, South Africa

Substudy in Progress

CERT-SNAP

Combination Cefazolin with Ertapenem for methicillin-susceptible Staphylococcus aureus bacteremia.

Canada

Substudy in Progress

Cell-free DNA

A Versatile Analyte to Monitor Complications and Guide Treatment Duration in Staphylococcus aureus Bacteremia

Canada

Substudy in Progress

SNAP-strat

SNAPstrat: Patient stratification using SAB sub-phenotypes

Any Interested

Substudy in Progress

Bacteriuria

Bacteriuria

What will the substudy involve - more information

Where will substudy data be collected and stored?

Where will substudy isolates be collected and stored?

SNAP Proposals

C-SNAP

PWID

Cef vs Pen

CERT-SNAP

Cell-free DNA

SNAP-strat

Index

Further Info

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