C-SNAP is a sub-study of the SNAP trial that will prospectively analyse plasma vitamin C level along with other data (patients, disease and treatment factors) collected from patients enrolled on the SNAP trial over 12 months.
This sub-study aims to:
i) describe estimate prevalence of hypovitaminosis C and vitamin C deficiency in patients with SAB
ii) explore whether Vitamin C deficiency develops or worsens in the early stages of management for SAB and sepsis.
iii) examine associations between Vitamin C deficiency on admission and other patient, disease and treatment factors.
iv) provide pilot data informing the feasibility a randomised controlled study of early Vitamin C replacement.
Lead Investigator: Dr Paul Huggan, Dr Hani Mohd Adnan, Dr Katie Walland - Te Whatu Ora Waikato, Pembroke Street, Hamilton, New Zealand.
SNAP Trial
SNAPstrat: Patient stratification using SAB sub-phenotypes
Cefazolin Versus Penicillin for Penicillin-Susceptible Staphylococcus aureus Bacteremia: A Secondary Analysis of the SNAP Backbone Trials
Significance of S. aureus bacteriuria in patients hospitalized with S. aureus bacteremia
A statistical genomics framework to improve prediction of treatment outcomes of Staphylococcus aureus bacteraemia (SAB)
